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Saturated Fatty Acid Emulsions Open the Blood–Brain Barrier and Promote Drug Delivery in Rat Brains
Kyoung Su Sung, Won Ho Cho, Seung Heon Cha, Yong-Woo Kim, Seon Hee Choi, Hak Jin Kim, Mi Sook Yun
Pharmaceutics 2024, 16(2), 246; https://doi.org/10.3390/pharmaceutics16020246
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Unsaturated free fatty acid emulsion infusion into carotid artery enhances drug delivery to the rat brain.
Kim YW, Choi SH, Choi KJ, Kim HJ, Kang JS, Hong DJ.
Brain Behav. 2023 Jun;13(6):e2994. doi: 10.1002/brb3.2994. Epub 2023 May 22.
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Triolein emulsion enhances temozolomide brain delivery: an experimental study in rats
Seung WB, Cha SH, Kim HJ, Choi SH, Lee J, Kwak D, Hyun Woo K, You JW, Kim YW, Kim SK, Lee DS.
Drug Deliv. 2021 Dec;28(1):2373-2382. doi: 10.1080/10717544.2021.1998247.
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Early development of vasogenic edema in experimental cerebral fat embolism in cats: correlation with MRI and electron microscopic findings.
Kim HJ, Lee CH, Lee SH, Cho BM, Kim HK, Park BR, Ye SY, Jeon GR, Chang KH.
Invest Radiol. 2001. Aug;36(8):460-9.
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Experimental cerebral fat embolism: embolic effects of triolein and oleic acid depicted by MR imaging and electron microscopy.
Kim HJ, Lee JH, Lee CH, Lee SH, Moon TY, Cho BM, Kim HK, Park BR, Chang KH.
AJNR Am J Neuroradiol. 2002. Oct;23(9):1516-23.
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Magnetic resonance imaging and histologic findings of experimental cerebral fat embolism.
Kim HJ, Lee CH, Lee SH, Moon TY.
Invest Radiol. 2003 Oct;38(10):625-34.
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Effect of triolein emulsion on the blood-testis barrier in cats.
Kim KN, Kim HJ, Lee SD, Moon TY, Lee SH, Lee JW, Lee TH.
Invest Radiol. 2004 Jul;39(7):445-9.
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Reversible MR changes in the cat brain after cerebral fat embolism induced by triolein emulsion.
Kim HJ, Lee CH, Kim HG, Lee SD, Son SM, Kim YW, Eun CK, Kim SM.
AJNR Am J Neuroradiol. 2004 Jun-Jul;25(6):958-63.
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A model for research on the blood-brain barrier disruption induced by unsaturated fatty acid emulsion.
Kim HJ, Pyeun YS, Kim YW, Cho BM, Lee TH, Moon TY, Suh KT, Park BR.
Invest Radiol. 2005 May;40(5):270-6.
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The study of cerebral hemodynamics in the hyperacute stage of fat embolism induced by triolein emulsion.
Kim YW, Kim HJ, Cho BM, Moon TY, Eun CK.
AJNR Am J Neuroradiol. 2006 Feb;27(2):398-401.
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The steroid effect on the blood-ocular barrier change induced by triolein emulsion as seen on contrast-enhanced MR images.
Lee JY, Eun CK, Kim YW, Kim HJ, Jung YJ, Jae SY, Cho BM, Choi SH.
Korean J Radiol. 2008 May-Jun;9(3):205-11.
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Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Baik SK, Kim YW, Kim HJ, Lee JW, Cho BM, Kim DH, Choi SH, Lee SH, Chang KH.
Acta Radiol. 2008 Dec;49(10):1174-81. doi: 10.1080/02841850802512449.
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Effect of fat embolism with triolein emulsion on blood-retinal barrier.
Lee JE, Jea SY, Oum BS, Kim HJ, Ohn YH.
Ophthalmic Res. 2009;41(1):14-20. doi: 10.1159/000162112. Epub 2008 Oct 13.
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Intra-arterial delivery of triolein emulsion increases vascular permeability in skeletal muscles of rabbits.
Kim HJ, Kim YW, Lee IS, Song JW, Jeong YJ, Choi SH, Choi KU, Suh KT, Cho BM.
Acta Vet Scand. 2009 Jul 16;51:30. doi: 10.1186/1751-0147-51-30.
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Blood-brain barrier experiments with clinical magnetic resonance imaging and an immunohistochemical study.
Park JW, Kim HJ, Song GS, Han HS.
J Korean Neurosurg Soc. 2010 Mar;47(3):203-9. doi: 10.3340/jkns.2010.47.3.203. Epub 2010 Mar 31.
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MRI of the cat brain in the study of vascular permeability after intraarterial carotid injection of triolein.
Ryu JH, Jeong YJ, Kim HJ, Kim DH, Kim DC, Kim MJ, Kim YW, Choi SH, Cho BM, Moon TY.
Acta Radiol. 2010 Jun;51(5):563-8. doi: 10.3109/02841851003674538. Erratum in: Acta Radiol. 2010 Sep;51(7):767.
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Immediate break-down of blood retinal barrier by infusion of triolein emulsion observed by fluorescein angiography.
Lee IS, Lee JE, Kim HJ, Song JW, Choi SH.
Curr Eye Res. 2011 Apr;36(4):358-63. doi: 10.3109/02713683.2010.548894. Epub 2011 Jan 28.
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Prominent hypointense veins on susceptibility weighted image in the cat brain with acute infarction: DWI, SWI, and PWI.
Kim YW, Kim HJ, Choi SH, Kim DC.
Acta Radiol. 2013 Oct 17.
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Hemorrhage in cerebral fat embolisms in a cat model using triolein dependent on the physical properties of triolein.
Kim YW, Kim HJ, Choi SH, Cho B, Hwangbo L, Kim DC.
Jpn J Radiol. 2014 Jan;32(1):30-7. doi: 10.1007/s11604-013-0265-x. Epub 2013 Nov 28.
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Transient blood brain barrier disruption induced by oleic acid is mediated by nitric oxide.
Han HS, Jang JH, Park JS, Kim HJ, Kim JK.
Curr Neurovasc Res. 2013 Nov;10(4):287-96.
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Effect of intra-arterial infusion with triolein emulsion on rabbit liver.
Kim YW, Park YM, Yoon S, Kim HJ, Park DY, Cho BM, Choi SH.
World J Gastroenterol. 2014;20(20):14442-9.
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The minimum percentage of triolein emulsion for studying cerebral vascular permeability with least brain edema.
Choi SH, Kim HJ, Hwangbo L, Kim YW.
Iran J Radiol. 2014;11(4):
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Distribution study of cisplatin in rat kidney and liver cancer tissues by using liquid chromatography electrospray inonization tendem mass spectrometry.
Bandu R, Ahn HS, Lee JW, Kim YW, Choi SH, Kim HJ, Kim KP.
J Mass Specto 2015;50:844-853
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Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric (LC/ESI-MS/MS) Study for the Identification and Characterization of In Vivo Metabolites of Cisplatin in Rat Kidney Cancer Tissues: Online Hydrogen/Deuterium (H/D) Exchange Study.
Raju Bandu, Hyun Soo Ahn, Joon Won Lee, Yong Woo Kim, Seon Hee Choi, Hak Jin Kim, Kwang Pyo Kim.
PLOS ONE | DOI:10.1371/journal.pone.0134027 August 5, 2015
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Triolein Emulsion Infusion Into the Carotid Artery Increases Brain Permeability to Anticancer Agents.
Hak Jin Kim, Yong-Woo Kim, Seon Hee Choi, Byung Mann Cho, Bandu Raju, Hyun Soo Ahn. KwangPyo Kim.
Neurosurgery 2016;78:726-733
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A liquid chromatography electrospray ionization tandem mass spectrometric study (LC/ESI-MS/MS) of in vivo metabolites of cisplatin in rat liver and brain tissues: deuterated experiments.
Raju Bandu, Hak Jin Kim, Hyuck Jun Mok, Kwang Pyo Kim.
RSC Adv., 2015, 5, 89951
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Functional end-arterial circulation of the choroid assessed by using fat embolism and electric circuit simulation.
Ji Eun Lee, Ki Su Ahn, Keun Heung Park, Kang Yeun Pak, Hak Jin Kim, Ik Soo Byon, Sung Who Park.
Scientific Reports | 7: 2490 | DOI:10.1038/s41598-017-02695-z
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Morphologic mechanisms of increased vascular permeability of triolein emulsion to the blood-brain barrier.
Yuri Sol, Seon Hee Choi, Hak Jin Kim, Yong-Woo Kim, Byung Mann Cho, Hyung Soo Han, Ki J Choi.
Microscopy 2017, 1-5 doi: 10.1093/jmicro/dfx026
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Doxorubicin concentration in brain remains high for one day after triolein emulsion infusion induced BBB opening.
In Sook Lee, Hak Jin Kim, Seon Hee Choi, Yong-woo Kim & Ki Joo Choi.
Int J Neurosci 2020, VOL. 130, NO. 8, 770–776
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Cerebral angiography using transauricular access in a rabbit model: a new technique.
Hak Jin Kim, Seon Hee Choi, So-Hyeon Kim, Yong-Woo Kim, Byung Hak Jhun, Deug-Woo Lee, Jin-Wook Yoo.
Acta Radiol 2020;0:1-7, DOI: 10.1177/0284185120915672
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Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver.
Yong-Woo Kim, Hak Jin Kim, Byung Mann Cho, Seon Hee Choi.
World J Gastroenterol 2021;14:152-161